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dc.date.accessioned 2012-02-03T15:24:24Z
dc.date.available 2012-02-03T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8409
dc.description.abstract The ternary solid dispersion systems of poorly water soluble olmesartan medoxomil (OLM) were prepared by conventional kneading method in order to improve its physicochemical performance. A 32 full factorial design approach was employed to optimize influence of concentration of polyvinylpyrrolidone K30 (PVP) and poloxamer 407 (PLX) on physicochemical characteristics of these dispersions. All formulations were characterized by XRPD, DSC and dissolution studies. Physical studies revealed complete loss of crystallinity and formation of uniform molecular dispersion of OLM in its ternary systems. All dispersion systems showed significant improvement in dissolution profile in comparison to pure drug alone (p < 0.001). The optimized formulation provided superior solubility and dissolution behaviour (F1; DP2 : 68.43 ± 2.8 %) of OLM suggesting optimum ratio of carrier system. The kinetic study of dissolution displayed to follow the Korsmeyer-Peppas model (r2 = 0.9835). es
dc.format.extent 2011-2015 es
dc.language en es
dc.subject kneading; ternary systems; olmesartan medoxomil es
dc.subject Análisis Factorial es
dc.subject Cinética es
dc.title Development and characterization of ternary solid dispersion systems of olmesartan medoxomil es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_21.pdf es
sedici.creator.person Rao, J. Venkateswara es
sedici.creator.person Pore, Yogesh V. es
sedici.creator.person Shinde, Vikram R. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001897 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 10 es


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