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dc.date.accessioned 2012-02-03T18:15:51Z
dc.date.available 2012-02-03T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://hdl.handle.net/10915/8414
dc.description.abstract A fast and reliable method for the determination of voriconazole in oral fluid using microextraction by packed sorbent and liquid chromatography with fluorescence detection was developed and validated. MEPS was performed at basic pH with only 50 μL of oral fluid and the extract was injected without an evaporation step. The overall procedure, including extraction and chromatographic analysis, took only 15 min. Voriconazole and internal standard were separated on a Lichrospher RP 8ec column (250 x 4 mm, particle diameter 5 μm) eluted with a mobile phase composed of phosphate pH 2.3 (containing 0.1 % triethylamine) and acetonitrile (64:36, v/v) at a flow rate of 1.4 mL min-1 . Total run time was 11 min, with detection being performed with excitation at 254 and emission at 372 nm. The method was successfully applied to oral fluid samples, with voriconazole concentrations presenting an average of 57.6 % of those measured in paired plasma samples. es
dc.format.extent p. 2043-2047 es
dc.language en es
dc.title Fast determination of voriconazole in oral fluid using microextractionby packed sorbent and HPLC with fluorescence detection es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_26.pdf es
sedici.creator.person Antunes, Marina V. es
sedici.creator.person Linden, Rafael es
sedici.creator.person Pasqualotto, Alessandro C. es
sedici.creator.person Andreolla, Huander F. es
sedici.creator.person Spaniol, Bárbara es
sedici.creator.person Bordin, Natália A. es
sedici.subject.materias Farmacia es
sedici.subject.decs Agentes Antifúngicos es
sedici.subject.decs Cromatografía es
sedici.subject.decs Monitoreo de Drogas es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001902 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 10 es


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