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dc.date.accessioned 2012-03-28T14:01:14Z
dc.date.available 2012-03-28T03:00:00Z
dc.date.issued 2012
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8428
dc.description.abstract Anthraquinones-rich extracts of Heterophyllaea pustulata Hook f. (Rubiaceae) exhibited in vitro antiviral activity against Herpes Simplex Virus Type I, from which several anthraquinones (AQs) were isolated and identified. The Maximum Non-Cytotoxic Concentration (MNCC), the subtoxic concentration (SubTC), and the CC50 of each AQ were determined on a mammalian eukaryotic cell line (Vero cells) by means of Neutral Red uptake assay; the cytopathic effect was simultaneously evaluated by optical microscopy. The range of concentrations where each AQ did not exhibit cytotoxicity was established, which is limited by the MNCC: rubiadin 1-methyl ether, damnacanthol and pustuline were found to be markedly less cytotoxic. To the remaining AQs, we could estimate a SubTC (about 10 μg/mL) that assures 80 % cellular viability. Therefore, we determined a concentration range which could be used to evaluate the antiviral effect of each AQ since it ensures the viability of the host cell. es
dc.format.extent 51-56 es
dc.language en es
dc.subject Toxicidad es
dc.subject Células Vero es
dc.subject Superóxidos es
dc.subject Antraquinonas es
dc.title Determination of non-toxic and subtoxic concentrations of potential antiviral natural anthraquinones en
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_8.pdf es
sedici.creator.person Núñez Montoya, Susana C. es
sedici.creator.person Contigiani, Marta S. es
sedici.creator.person Marioni, Juliana es
sedici.creator.person Aguilar, Juan J. es
sedici.creator.person Grasso, Sergio es
sedici.creator.person Comini, Laura Raquel es
sedici.creator.person Konigheim, Brenda S. es
sedici.subject.materias Farmacia es
sedici.description.fulltext true es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001916 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 31, no. 1 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)