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dc.date.accessioned 2019-10-31T17:52:42Z
dc.date.available 2019-10-31T17:52:42Z
dc.date.issued 2003
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/84584
dc.description.abstract The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength after which occurs a slow force increase (SFR) that takes several minutes to fully develop. The SFR was detected in a wide variety of experimental preparations including isolated myocytes, papillary muscles and/or trabeculae, left ventricle strips of failing human myocardium, in vitro isovolumic and in vivo volume-loaded hearts. It was established that the initial increase in force is due to an increase in myofilament Ca2+ responsiveness, whereas the SFR results from an increase in the Ca2+ transient. However, the mechanism(s) for this increase in the Ca2+ transient has remained undefined until the proposal of Na+/H+ exchanger (NHE) activation by stretch. Studies in multicellular cardiac muscle preparations from cat, rabbit, rat and failing human heart have shown evidence that the stretch induces a rise in intracellular Na+ ([Na+]i) through NHE activation, which subsequently leads to an increase in Ca2+ transient via reverse-mode Na+/Ca2+ (NCX) exchange. These experimental data agree with a theoretical ionic model of cardiomyocytes that predicted an increased Na+ influx and a concurrent increase in Ca2+ entry through NCX as the cause of the SFR to muscle stretch. However, there are aspects that await definitive demonstration, and perhaps subjected to species-related differences like the possibility of an autocrine/paracrine loop involving angiotensin II and endothelin as the underlying mechanism for stretch-induced NHE activation leading to the rise in [Na+]i and reverse-mode NCX. en
dc.format.extent 953-960 es
dc.language en es
dc.subject Angiotensin es
dc.subject Endothelins es
dc.subject Na/Ca-exchanger es
dc.subject Na/H-exchanger es
dc.subject Stretch/m-e coupling es
dc.title Stretch-elicited Na+/H+ exchanger activation: The autocrine/paracrine loop and its mechanical counterpart en
dc.type Articulo es
sedici.identifier.other doi:10.1016/S0008-6363(02)00768-X es
sedici.identifier.other eid:2-s2.0-0345471067 es
sedici.identifier.issn 0008-6363 es
sedici.creator.person Cingolani, Horacio Eugenio es
sedici.creator.person Pérez, Néstor Gustavo es
sedici.creator.person Pieske, Burket es
sedici.creator.person Lewinski, Dirk von es
sedici.creator.person Camilión de Hurtado, María Cristina es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Médicas es
mods.originInfo.place Centro de Investigaciones Cardiovasculares es
sedici.subtype Revision es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Cardiovascular Research es
sedici.relation.journalVolumeAndIssue vol. 57, no. 4 es
sedici.rights.sherpa * RoMEO: verde* Pre-print del autor: can* Post-print del autor: can* Versión de editor/PDF:cannot* Condiciones:>>El pre-print sólo puede depositarse antes de la aceptación>>El pre-print debe acompañarse de una declaración establecida (ver enlace)>>El pre-print no debe reemplazarse por el post-print, sino que se enlazará a la versión publicada con una declaración establecida corregida>>Pre-print on author's personal website, employer website, free public server or pre-prints in subject area>>Post-print en el sitio web personal del autor de manera inmediata>>Post-print in Institutional repositories or Central repositories after 12 months embargo>>La versión de editor/PDF no puede utilizarse>>La fuente editorial debe reconocerse>>Debe ir enlazado a la versión de editor>>La copia archivada debe acompañarse de la frase establecida (ver Política)>>El editor depositará copia en PubMed Central en nombre de los autores financiados por el NIH>>Publisher last contacted on 19/02/2015* Link a Sherpa: http://sherpa.ac.uk/romeo/issn/0008-6363/es/


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)