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dc.date.accessioned 2019-11-01T17:57:45Z
dc.date.available 2019-11-01T17:57:45Z
dc.date.issued 2002
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/84668
dc.description.abstract The goal of the present study was to evaluate the effects of Ang II on the current produced by the Na+-Ca2+ exchanger (INCX) working in the reverse mode and the possible autocrine role played by the release of endothelin (ET) in these actions. INCX was studied in isolation in cat cardiac myocytes. Angiotensin II (Ang II) (100 nmol/L) increased INCX at potentials higher than 0 mV (at +60 mV: 2.07±0.22 pA/pF in control versus 2.73±0.22 pA/pF in Ang II, n = 9; P < 0.05). The increase in INCX induced by Ang II was prevented by the treatment of the cells with the unspecific blocker of the ET receptors, TAK 044 (1 μmol/L) (at +60 mV: 2.15±0.27 pA/pF in control versus 2.01±0.26 pA/pF in Ang II, n=5, NS). These results show, for the first time, that the effect of Ang II on INCX is the result of the autocrine actions of ET released by the octapeptide. en
dc.format.extent 374-376 es
dc.language en es
dc.subject Angiotensin II es
dc.subject Cardiac myocytes es
dc.subject Endothelin es
dc.subject Sodium-calcium exchanger es
dc.title Autocrine stimulation of cardiac Na+-Ca2+ exchanger currents by endogenous endothelin released by angiotensin II en
dc.type Articulo es
sedici.identifier.other doi:10.1161/hh0402.105373 es
sedici.identifier.other eid:2-s2.0-0037040829 es
sedici.identifier.issn 0009-7330 es
sedici.creator.person Aiello, Ernesto Alejandro es
sedici.creator.person Villa Abrille, María Celeste es
sedici.creator.person Cingolani, Horacio Eugenio es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Médicas es
mods.originInfo.place Centro de Investigaciones Cardiovasculares es
sedici.subtype Comunicacion es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Circulation Research es
sedici.relation.journalVolumeAndIssue vol. 90, no. 4 es
sedici.rights.sherpa * RoMEO: amarillo* Pre-print del autor: can* Post-print del autor: restricted* Versión de editor/PDF:cannot* Condiciones:>>Author's pre-print on pre-print server only>>Must inform publisher of any pre-print deposit>>Author's pre-print must not be updated with future versions>>Author's post-print on Institutional repository or funding agency repository>>En un servidor sin ánimo de lucro>>La versión de editor/PDF no puede utilizarse>>Publisher will automatically deposit authors post-print in PubMed Central for NIH funded authors after 12 months>>Publisher will automatically deposit authors post-print in PubMed Central for HHMI and Wellcome Trust funded authors after 6 months>>Authors may place a 'toll-free' link to their article on authors' personal website or institutional website without embargo>>Debe enlazar a la versión de editor con DOI>>Publisher last contacted on 07/06/2018* Link a Sherpa: http://sherpa.ac.uk/romeo/issn/0009-7330/es/


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)