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dc.date.accessioned 2019-11-05T14:47:37Z
dc.date.available 2019-11-05T14:47:37Z
dc.date.issued 2001
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/84943
dc.description.abstract This study was designed to gain additional insight into the mechanism of the slow force response (SFR) to stretch of cardiac muscle. SFR and changes in intracellular Na+ concentration ([Na+]i) were assessed in cat papillary muscles stretched from 92% to ≈98% of Lmax. The SFR was 120±0.6% (n=5) of the rapid initial phase and coincided with an increase in [Na+]i. The SFR was markedly depressed by Na+-H+ exchanger inhibition, AT1 receptor blockade, nonselective endothelin-receptor blockade and selective ETA-receptor blockade, extracellular Na+ removal and inhibition of the reverse mode of the Na+-Ca2+ exchange by KB-R7943. KB-R7943 prevented the SFR but not the increase in [Na+]i. Inhibition of endothelin-converting enzyme activity by phosphoramidon suppressed both the SFR and the increase in [Na+]i. The SFR and the increase in [Na+]i after stretch were both present in muscles with their endothelium (vascular and endocardial) made functionally inactive by Triton X-100. In these muscles, phosphoramidon also suppressed the SFR and the increase in [Na+]i. The data provide evidence that the last step of the autocrine-paracrine mechanism leading to the SFR to stretch is Ca2+ entry through the reverse mode of Na+-Ca2+ exchange. en
dc.format.extent 376-382 es
dc.language en es
dc.subject Angiotensin II es
dc.subject Endothelin es
dc.subject Myocardial stretch es
dc.subject Na+-Ca2+ exchange es
dc.subject Na+-H+ exchange es
dc.title Reverse mode of the Na+-Ca2+ exchange after myocardial stretch en
dc.type Articulo es
sedici.identifier.other doi:10.1161/01.RES.88.4.376 es
sedici.identifier.other eid:2-s2.0-0035793924 es
sedici.identifier.issn 0009-7330 es
sedici.title.subtitle Underlying mechanism of the slow force response en
sedici.creator.person Pérez, Néstor Gustavo es
sedici.creator.person Camilión de Hurtado, María Cristina es
sedici.creator.person Cingolani, Horacio Eugenio es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Médicas es
mods.originInfo.place Centro de Investigaciones Cardiovasculares es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Circulation Research es
sedici.relation.journalVolumeAndIssue vol. 88, no. 4 es
sedici.rights.sherpa * RoMEO: amarillo* Pre-print del autor: can* Post-print del autor: restricted* Versión de editor/PDF:cannot* Condiciones:>>Author's pre-print on pre-print server only>>Must inform publisher of any pre-print deposit>>Author's pre-print must not be updated with future versions>>Author's post-print on Institutional repository or funding agency repository>>En un servidor sin ánimo de lucro>>La versión de editor/PDF no puede utilizarse>>Publisher will automatically deposit authors post-print in PubMed Central for NIH funded authors after 12 months>>Publisher will automatically deposit authors post-print in PubMed Central for HHMI and Wellcome Trust funded authors after 6 months>>Authors may place a 'toll-free' link to their article on authors' personal website or institutional website without embargo>>Debe enlazar a la versión de editor con DOI>>Publisher last contacted on 07/06/2018* Link a Sherpa: http://sherpa.ac.uk/romeo/issn/0009-7330/es/


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)