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dc.date.accessioned 2019-11-08T15:32:19Z
dc.date.available 2019-11-08T15:32:19Z
dc.date.issued 2013
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/85231
dc.description.abstract Our objective was to assess the antioxidant properties and the effects against the reperfusion injury of a nonalcoholic extract obtained by fermentation from the Colombian blueberry, mortiño (Vaccinium meridionale Swartz, Ericaceae). Antioxidant properties were assessed by in vitro systems. To examine the postischemic myocardial function, isolated rat hearts were treated 10 min before ischemia and during the first 10 min of reperfusion with the extract. To analyze the participation of nitric oxide (NO), other experiments were performed in the presence of nitric oxide synthase (NOS) inhibition with NG-nitro-L-arginine methyl ester (L-NAME). In cardiac tissue thiobarbituric acid reactive substances (TBARS) concentration, reduced glutathione (GSH) content, endothelial NOS (eNOS), and Akt expression were also measured. The blueberry extract showed higher total phenols and anthocyanins contents, scavenging activity of superoxide radical and systolic and diastolic function was improved, TBARS diminished, GSH was partially preserved, and both NOS and Akt expression increased in hearts treated with the extract. These beneficial effects were lost when eNOS was inhibited. In resume, these data show that the increase of eNOS expression via Akt and the scavenging activity contribute to the cardioprotection afforded by acute treatment with Colombian blueberry extract against ischemia and reperfusion injury. en
dc.language en es
dc.subject Anthocyanins es
dc.subject Juices es
dc.subject Anthocyanin degradation es
dc.title Antioxidant activity and cardioprotective effect of a nonalcoholic extract of Vaccinium meridionale Swartz during ischemia-reperfusion in rats en
dc.type Articulo es
sedici.identifier.other doi:10.1155/2013/516727 es
sedici.identifier.other eid:2-s2.0-84874546644 es
sedici.identifier.issn 1741-427X es
sedici.creator.person Lopera, Yasmin E. es
sedici.creator.person Fantinelli, Juliana Catalina es
sedici.creator.person González Arbeláez, Luisa Fernanda es
sedici.creator.person Rojano, Benjamín es
sedici.creator.person Ríos, José Luis es
sedici.creator.person Schinella, Guillermo Raúl es
sedici.creator.person Mosca, Susana María es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Médicas es
mods.originInfo.place Centro de Investigaciones Cardiovasculares es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Evidence-based Complementary and Alternative Medicine es
sedici.relation.journalVolumeAndIssue vol. 2013 es
sedici.rights.sherpa * Color: green * Pre-print del autor: si * Post-print del autor: si * Versión de editor/PDF:si * Condiciones: >>On any website >>Publisher's version/PDF may be used >>Creative Commons Attribution License >>All titles are open access journals * Link a Sherpa: http://sherpa.ac.uk/romeo/issn/1741-427X/es/


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)