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dc.date.accessioned 2019-11-08T17:45:41Z
dc.date.available 2019-11-08T17:45:41Z
dc.date.issued 2014
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/85265
dc.description.abstract Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment. en
dc.format.extent 5225-5237 es
dc.language en es
dc.subject Animal models es
dc.subject Apoptosis es
dc.subject Metastasis es
dc.subject Protein kinase C (PKC) es
dc.subject Survival es
dc.subject Tumorigenesis es
dc.title Protein kinase C and cancer: what we know and what we do not en
dc.type Articulo es
sedici.identifier.other doi:10.1038/onc.2013.524 es
sedici.identifier.other eid:2-s2.0-85027928647 es
sedici.identifier.issn 0950-9232 es
sedici.creator.person Garg, R. es
sedici.creator.person Benedetti, L.G. es
sedici.creator.person Abera, M. B. es
sedici.creator.person Wang, H. es
sedici.creator.person Abba, Martín Carlos es
sedici.creator.person Kazanietz, M.G. es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Centro de Investigaciones Inmunológicas Básicas y Aplicadas es
sedici.subtype Revision es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Oncogene es
sedici.relation.journalVolumeAndIssue vol. 33, no. 45 es
sedici.rights.sherpa * Color: yellow * Pre-print del autor: si * Post-print del autor: restringido * Versión de editor/PDF:no * Condiciones: >>Author's pre-print applies to research content only (excludes reviews) >>On authors personal webpage, institutional repository or funder repository >>Non-commercial use only >>Publisher's version/PDF no be used >>Authors retain copyright >>Published source must be acknowledged and DOI cited >>Must link to publisher version >>Author post-prints of subscription articles are subject to Springer Nature re-use terms >>Research content only (excludes reviews) * Link a Sherpa: http://sherpa.ac.uk/romeo/issn/0950-9232/es/

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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)