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dc.date.accessioned | 2019-11-11T15:34:33Z | |
dc.date.available | 2019-11-11T15:34:33Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/85323 | |
dc.description.abstract | Background: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume fraction (CVF) were studied in rats. LVM and LVF were evaluated in animals and humans by echocardiography and LVM index (LVMI) was obtained. Results: LVMI, myocyte area and CVF were similar in males and females of 1-month-old rats. LVMI in children was similar in both genders. In contrast, in 6-month-old rats (5 males and 5 females), LVMI (17.7 ± 0.7 mg/mm vs. 10.1 ± 0.2 mg/mm; p < 0.01), and myocyte area (4572.5 ± 72.6 μm2 vs. 3293.85 ± 57.8 μm2, p < 0.01) were higher in male animals without differences in CVF. Men (n = 25) exhibited greater LVMI than women (n = 25) (77.4 ± 3.2 g/m2 vs. 63.3 ± 1.8 g/m2, p < 0.01), whereas the LVF was higher in women (105.9 ± 2.9% vs. 95.3 ± 3.5%, p < 0.01). Conclusions: There is a clear gender-associated impact on LVM with aging in humans and rats. Similar CVF and LVF associated to greater myocyte size and LVM in male rats suggest a process of physiological response. However, the increase in cardiac mass without an associated improved cardiac function in men in comparison to women could likely represent a potential disadvantage in the adaptive response during growth. | en |
dc.format.extent | 53-59 | es |
dc.language | en | es |
dc.subject | Cardiac function | es |
dc.subject | Cardiac hypertrophy | es |
dc.subject | Cardiac myocytes | es |
dc.subject | Sex differences | es |
dc.title | Gender differences in cardiac left ventricular mass and function: clinical and experimental observations | en |
dc.type | Articulo | es |
sedici.identifier.other | doi:10.5603/CJ.a2013.0105 | es |
sedici.identifier.other | eid:2-s2.0-84894310211 | es |
sedici.identifier.issn | 1897-5593 | es |
sedici.creator.person | Escudero, Eduardo Manuel | es |
sedici.creator.person | Orlowski, Alejandro | es |
sedici.creator.person | Díaz, Alberto Alejandro | es |
sedici.creator.person | Pinilla, Oscar Andrés | es |
sedici.creator.person | Ennis, Irene Lucía | es |
sedici.creator.person | Aiello, Ernesto Alejandro | es |
sedici.subject.materias | Ciencias Médicas | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Facultad de Ciencias Médicas | es |
sedici.subtype | Articulo | es |
sedici.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | Cardiology Journal | es |
sedici.relation.journalVolumeAndIssue | vol. 21, no. 1 | es |
sedici.rights.sherpa | * Color: gray * Pre-print del autor: unknown * Post-print del autor: unknown * Versión de editor/PDF:unknown * Condiciones: >>This publisher's policies have not been checked by Color. >>DOAJ says it is an open access journal, but this may only mean that it is freely available to read. >>Most open access publishers also permit self-archiving and re-use, but some do not. >>Do not assume that self-archiving is allowed, unless it is published under a Creative Commons license. >>Please contact the publisher for further information if necessary >>Email romeo@jisc.ac.uk if you wish to suggest adding this publisher properly to Color. * Link a Sherpa: http://sherpa.ac.uk/romeo/issn/1897-5593/es/ |