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dc.date.accessioned | 2019-11-13T13:48:01Z | |
dc.date.available | 2019-11-13T13:48:01Z | |
dc.date.issued | 2013 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/85471 | |
dc.description.abstract | Mitochondrial damage has been associated with early steps of cardiac dysfunction in heart subjected to ischemic stress, oxidative stress and hypertrophy. A common feature for the mitochondrial deterioration is the loss of the mitochondrial membrane potential (δψm) with the concomitant irreversible opening of the mitochondrial permeability transition pore (MPTP) which follows the mitochondrial Ca2+ overload, and the subsequent mitochondrial swelling. We have recently characterized the expression of the Na+/H+ exchanger 1 (mNHE1) in mitochondrial membranes. This surprising observation provided a unique target for the prevention of the Ca2+-induced MPTP opening, based on the inhibition of the NHE1 m. In this line, inhibition of NHE1 m activity and/or reduction of NHE1 m expression decreased the Ca2+-induced mitochondrial swelling and the release of reactive oxygen species (ROS) in isolated cardiac mitochondria and preserved the δψm in isolated cardiomyocytes. Mitochondrial NHE1 thus represents a novel target to prevent cardiac disease, opening new avenues for future research. | en |
dc.language | en | es |
dc.subject | Ischemia | es |
dc.subject | Mitochondrial permeability transition pore | es |
dc.subject | Mitochondrial swelling | es |
dc.subject | NHE1 | es |
dc.subject | Sirna | es |
dc.title | Mitochondrial NHE1: a newly identified target to prevent heart disease | en |
dc.type | Articulo | es |
sedici.identifier.other | doi:10.3389/fphys.2013.00152 | es |
sedici.identifier.other | eid:2-s2.0-84884553350 | es |
sedici.identifier.issn | 1664-042X | es |
sedici.creator.person | Álvarez, Bernardo Víctor | es |
sedici.creator.person | Villa Abrille, María Celeste | es |
sedici.subject.materias | Ciencias Médicas | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Facultad de Ciencias Médicas | es |
mods.originInfo.place | Centro de Investigaciones Cardiovasculares | es |
sedici.subtype | Revision | es |
sedici.rights.license | Creative Commons Attribution 3.0 Unported (CC BY 3.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by/3.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | Frontiers in Physiology | es |
sedici.relation.journalVolumeAndIssue | vol. 4 | es |
sedici.rights.sherpa | * Color: green * Pre-print del autor: si * Post-print del autor: si * Versión de editor/PDF:si * Condiciones: >>On open access repositories >>Authors retain copyright >>Creative Commons Attribution License >>Published source must be acknowledged with citation >>First publication by Frontiers Media must be acknowledged >>Publisher's version/PDF may be used >>Articles are placed in PubMed Central immediately on behalf of authors. >>All titles are open access journals >>Publisher last reviewed on 24/07/2019 * Link a Sherpa: http://sherpa.ac.uk/romeo/issn/1664-042X/es/ |