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dc.date.accessioned 2019-11-13T13:48:01Z
dc.date.available 2019-11-13T13:48:01Z
dc.date.issued 2013
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/85471
dc.description.abstract Mitochondrial damage has been associated with early steps of cardiac dysfunction in heart subjected to ischemic stress, oxidative stress and hypertrophy. A common feature for the mitochondrial deterioration is the loss of the mitochondrial membrane potential (δψm) with the concomitant irreversible opening of the mitochondrial permeability transition pore (MPTP) which follows the mitochondrial Ca2+ overload, and the subsequent mitochondrial swelling. We have recently characterized the expression of the Na+/H+ exchanger 1 (mNHE1) in mitochondrial membranes. This surprising observation provided a unique target for the prevention of the Ca2+-induced MPTP opening, based on the inhibition of the NHE1 m. In this line, inhibition of NHE1 m activity and/or reduction of NHE1 m expression decreased the Ca2+-induced mitochondrial swelling and the release of reactive oxygen species (ROS) in isolated cardiac mitochondria and preserved the δψm in isolated cardiomyocytes. Mitochondrial NHE1 thus represents a novel target to prevent cardiac disease, opening new avenues for future research. en
dc.language en es
dc.subject Ischemia es
dc.subject Mitochondrial permeability transition pore es
dc.subject Mitochondrial swelling es
dc.subject NHE1 es
dc.subject Sirna es
dc.title Mitochondrial NHE1: a newly identified target to prevent heart disease en
dc.type Articulo es
sedici.identifier.other doi:10.3389/fphys.2013.00152 es
sedici.identifier.other eid:2-s2.0-84884553350 es
sedici.identifier.issn 1664-042X es
sedici.creator.person Álvarez, Bernardo Víctor es
sedici.creator.person Villa Abrille, María Celeste es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Médicas es
mods.originInfo.place Centro de Investigaciones Cardiovasculares es
sedici.subtype Revision es
sedici.rights.license Creative Commons Attribution 3.0 Unported (CC BY 3.0)
sedici.rights.uri http://creativecommons.org/licenses/by/3.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Frontiers in Physiology es
sedici.relation.journalVolumeAndIssue vol. 4 es
sedici.rights.sherpa * Color: green * Pre-print del autor: si * Post-print del autor: si * Versión de editor/PDF:si * Condiciones: >>On open access repositories >>Authors retain copyright >>Creative Commons Attribution License >>Published source must be acknowledged with citation >>First publication by Frontiers Media must be acknowledged >>Publisher's version/PDF may be used >>Articles are placed in PubMed Central immediately on behalf of authors. >>All titles are open access journals >>Publisher last reviewed on 24/07/2019 * Link a Sherpa: http://sherpa.ac.uk/romeo/issn/1664-042X/es/


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Creative Commons Attribution 3.0 Unported (CC BY 3.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution 3.0 Unported (CC BY 3.0)