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dc.date.accessioned 2019-11-22T17:06:14Z
dc.date.available 2019-11-22T17:06:14Z
dc.date.issued 2016
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/85963
dc.description.abstract Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious encephalitis, and serological testing for Sarcocystis neurona was negative. The filly was euthanized. Postmortem X-ray radiography of the cervical cephalic region identified not abnormalities, discounting spinal trauma. The histopathological analysis of serial transverse cerebellar sections by electron microscopy revealed morphological characteristics of apoptotic cells with pyknotic nuclei and degenerate mitochondria, cytoplasmic condensation and areas with absence of Purkinje cells, matching with CA histopathological characteristics. The indirect DNA test for CA was positive in the filly, and DNA test confirmed the CA carrier state in the parents and the recessive inheritance of the disease. To our knowledge this is the first report of a CA case in Argentina. en
dc.format.extent 259-262 es
dc.language en es
dc.subject Apoptosis es
dc.subject Arabian horses es
dc.subject Cerebellar abiotrophy es
dc.subject DNA es
dc.subject Purkinje cells es
dc.title First report of cerebellar abiotrophy in an Arabian foal from Argentina en
dc.type Articulo es
sedici.identifier.other doi:10.4314/ovj.v6i3.17 es
sedici.identifier.other eid:2-s2.0-85032391449 es
sedici.identifier.issn 2226-4485 es
sedici.creator.person Sadaba, Sebastián Andres es
sedici.creator.person Madariaga, G.J es
sedici.creator.person Corbi Botto, Claudia es
sedici.creator.person Carino, Mónica H. es
sedici.creator.person Zappa, María Eugenia es
sedici.creator.person Peral García, Pilar es
sedici.creator.person Olguín, Silvia Andrea es
sedici.creator.person Massone, Adriana Raquel es
sedici.creator.person Díaz, Silvina es
sedici.subject.materias Ciencias Veterinarias es
sedici.description.fulltext true es
mods.originInfo.place Instituto de Genética Veterinaria es
mods.originInfo.place Facultad de Ciencias Veterinarias es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Open Veterinary Journal es
sedici.relation.journalVolumeAndIssue vol. 6, no. 3 es
sedici.rights.sherpa * Color: gray * Pre-print del autor: unknown * Post-print del autor: unknown * Versión de editor/PDF:unknown * Condiciones: >>This publisher's policies have not been checked by Color. >>DOAJ says it is an open access journal, but this may only mean that it is freely available to read. >>Most open access publishers also permit self-archiving and re-use, but some do not. >>Do not assume that self-archiving is allowed, unless it is published under a Creative Commons license. >>Please contact the publisher for further information if necessary >>Email romeo@jisc.ac.uk if you wish to suggest adding this publisher properly to Color. * Link a Sherpa: http://sherpa.ac.uk/romeo/issn/2218-6050/es/


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)