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dc.date.accessioned | 2019-11-22T17:06:14Z | |
dc.date.available | 2019-11-22T17:06:14Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/85963 | |
dc.description.abstract | Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious encephalitis, and serological testing for Sarcocystis neurona was negative. The filly was euthanized. Postmortem X-ray radiography of the cervical cephalic region identified not abnormalities, discounting spinal trauma. The histopathological analysis of serial transverse cerebellar sections by electron microscopy revealed morphological characteristics of apoptotic cells with pyknotic nuclei and degenerate mitochondria, cytoplasmic condensation and areas with absence of Purkinje cells, matching with CA histopathological characteristics. The indirect DNA test for CA was positive in the filly, and DNA test confirmed the CA carrier state in the parents and the recessive inheritance of the disease. To our knowledge this is the first report of a CA case in Argentina. | en |
dc.format.extent | 259-262 | es |
dc.language | en | es |
dc.subject | Apoptosis | es |
dc.subject | Arabian horses | es |
dc.subject | Cerebellar abiotrophy | es |
dc.subject | DNA | es |
dc.subject | Purkinje cells | es |
dc.title | First report of cerebellar abiotrophy in an Arabian foal from Argentina | en |
dc.type | Articulo | es |
sedici.identifier.other | doi:10.4314/ovj.v6i3.17 | es |
sedici.identifier.other | eid:2-s2.0-85032391449 | es |
sedici.identifier.issn | 2226-4485 | es |
sedici.creator.person | Sadaba, Sebastián Andres | es |
sedici.creator.person | Madariaga, G.J | es |
sedici.creator.person | Corbi Botto, Claudia | es |
sedici.creator.person | Carino, Mónica H. | es |
sedici.creator.person | Zappa, María Eugenia | es |
sedici.creator.person | Peral García, Pilar | es |
sedici.creator.person | Olguín, Silvia Andrea | es |
sedici.creator.person | Massone, Adriana Raquel | es |
sedici.creator.person | Díaz, Silvina | es |
sedici.subject.materias | Ciencias Veterinarias | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Instituto de Genética Veterinaria | es |
mods.originInfo.place | Facultad de Ciencias Veterinarias | es |
sedici.subtype | Articulo | es |
sedici.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | Open Veterinary Journal | es |
sedici.relation.journalVolumeAndIssue | vol. 6, no. 3 | es |
sedici.rights.sherpa | * Color: gray * Pre-print del autor: unknown * Post-print del autor: unknown * Versión de editor/PDF:unknown * Condiciones: >>This publisher's policies have not been checked by Color. >>DOAJ says it is an open access journal, but this may only mean that it is freely available to read. >>Most open access publishers also permit self-archiving and re-use, but some do not. >>Do not assume that self-archiving is allowed, unless it is published under a Creative Commons license. >>Please contact the publisher for further information if necessary >>Email romeo@jisc.ac.uk if you wish to suggest adding this publisher properly to Color. * Link a Sherpa: http://sherpa.ac.uk/romeo/issn/2218-6050/es/ |