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dc.date.accessioned | 2019-11-25T14:56:26Z | |
dc.date.available | 2019-11-25T14:56:26Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/86057 | |
dc.description.abstract | The aim of this work was to assess the biological and food safety of two different beverages: Classic Coca Cola™ (CCC) and Caffeine-Free Coca Cola (CFCC). To this end, we determined the genotoxicological and biological effects of different doses of lyophilised CCC and CFCC and Caffeine (CAF), the main distinctive constituent. Their toxic/antitoxic, genotoxic/antigenotoxic, and chronic toxicity (lifespan assay) effects were determined in vivo using the Drosophila model. Their cytotoxic activities were determined using the HL-60 in vitro cancer model. In addition, clastogenic DNA toxicity was measured using internucleosomal fragmentation and SCGE assays. Their epigenetic effects were assessed on the HL-60 methylation status using some repetitive elements. The experimental results showed a slight chemopreventive effect of the two cola beverages against HL-60 leukaemia cells, probably mediated by nonapoptotic mechanisms. Finally, CCC and CAF induced a global genome hypomethylation evaluated in LINE-1 and Alu M1 repetitive elements. Overall, we demonstrated for the first time the safety of this famous beverage in in vivo and in vitro models. | en |
dc.language | en | es |
dc.subject | Biological and food safety | es |
dc.subject | Coca Cola | es |
dc.subject | Genotoxicological effects | es |
dc.subject | Biological effects | es |
dc.title | In Vivo and in Vitro Genotoxic and Epigenetic Effects of Two Types of Cola Beverages and Caffeine: A Multiassay Approach | en |
dc.type | Articulo | es |
sedici.identifier.other | doi:10.1155/2016/7574843 | es |
sedici.identifier.other | eid:2-s2.0-84978933455 | es |
sedici.identifier.issn | 2314-6133 | es |
sedici.creator.person | Mateo Fernández, Marcos | es |
sedici.creator.person | Merinas Amo, Tania | es |
sedici.creator.person | Moreno Millán, Miguel | es |
sedici.creator.person | Alonso Moraga, Ángeles | es |
sedici.creator.person | Demyda Peyrás, Sebastián | es |
sedici.subject.materias | Biología | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Instituto de Genética Veterinaria | es |
sedici.subtype | Articulo | es |
sedici.rights.license | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | BioMed Research International | es |
sedici.relation.journalVolumeAndIssue | vol. 2016 | es |
sedici.rights.sherpa | * Color: green * Pre-print del autor: can * Post-print del autor: can * Versión de editor/PDF:can * Condiciones: >>On any website >>Publisher's version/PDF may be used >>Creative Commons Attribution License >>All titles are open access journals * Link a Sherpa: http://sherpa.ac.uk/romeo/issn/2314-6133/es/ |