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dc.date.accessioned 2019-12-12T14:13:05Z
dc.date.available 2019-12-12T14:13:05Z
dc.date.issued 2017
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/87296
dc.description.abstract The effect of the urease immobilization method was studied on magnetic supports for the Biginelli/Hantzsch reaction. For this purpose, Fe3O4/SiO2 was modified with 3-Aminopropyl-Triethoxysilane and then activated with glutaraldehyde. A ratio of 500 mg of enzyme per gram of support at 4°C and 18 h were sufficient for the physical adsorption, while 24 h were required for covalent bonding. The Biginelli and Hantzsch reactions were used to evaluate urease application in multicomponent reactions (MCRs). The synthesis of 1,4-dihydropyrimidines was successfully performed using immobilized urease favoring the Hantzsch product. The magnetic properties of the supports allow easy separation, and the urease immobilized by both methods improved the enzymatic activity compared to that of free urease. en
dc.format.extent 377-384 es
dc.language en es
dc.subject Biginelli/Hantzsch reaction es
dc.subject magnetic supports es
dc.subject urease immobilized es
dc.title Synthesis of 1,4-dihydropyrimidines with immobilized urease: Effect of method immobilization on magnetic supports en
dc.type Articulo es
sedici.identifier.other doi:10.1515/gps-2016-0143 es
sedici.identifier.other eid:2-s2.0-85027058510 es
sedici.identifier.issn 2191-9542 es
sedici.creator.person Vargas, Annie Y. es
sedici.creator.person Rojas, Hugo A. es
sedici.creator.person Romanelli, Gustavo Pablo es
sedici.creator.person Martínez Zambrano, José Jobanny es
sedici.subject.materias Química es
sedici.description.fulltext true es
mods.originInfo.place Centro de Investigación y Desarrollo en Ciencias Aplicadas es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Green Processing and Synthesis es
sedici.relation.journalVolumeAndIssue vol. 6, no. 4 es
sedici.rights.sherpa * Color: yellow * Pre-print del autor: si * Post-print del autor: restricted * Versión de editor/PDF:restricted * Condiciones: >>Pre-print and abstract on author's personal website only >>Author's post-print on funder's repository or funder's designated repository at the funding agency's request or as a result of legal obligation. >>Publisher's version/PDF may be used, on author's personal website, editor's personal website or institutional repository >>Authors no deposit in subject repositories >>Published source must be acknowledged >>Must link to publisher version and article's DOI must be given * Link a Sherpa: http://sherpa.ac.uk/romeo/issn/2191-9542/es/


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)