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dc.date.accessioned 2019-12-13T18:24:54Z
dc.date.available 2019-12-13T18:24:54Z
dc.date.issued 2017
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/87426
dc.description.abstract Crohn's disease is an idiopathic disorder of the gut thought to be caused by a combination of environmental and genetic factors in susceptible individuals. It is characterized by chronic transmural inflammation of the terminal ileum and colon, with typical transmural lesions. Complications, including fibrosis, mean that between 40 and 70% of patients require surgery in the first 10 years after diagnosis. Presently, there is no evidence that the current therapies which dampen inflammation modulate or reverse intestinal fibrosis. In this review, we focus on cytokines that may lead to fibrosis and stenosis and the contribution of experimental models for understanding and treatment of gut fibrosis. en
dc.language en es
dc.subject Chronic inflammation es
dc.subject Crohn's disease es
dc.subject Cytokines es
dc.subject Extracellular matrix es
dc.subject Fibrosis es
dc.subject Fibrostenosis es
dc.subject Strictures es
dc.title The role of cytokines in the fibrotic responses in Crohn's disease en
dc.type Articulo es
sedici.identifier.other doi:10.3389/fmed.2017.00126 es
sedici.identifier.other eid:2-s2.0-85046950023 es
sedici.identifier.issn 2296-858X es
sedici.creator.person Curciarello, Renata es
sedici.creator.person Docena, Guillermo Horacio es
sedici.creator.person MacDonald, Thomas T. es
sedici.subject.materias Ciencias Exactas es
sedici.description.fulltext true es
mods.originInfo.place Instituto de Estudios Inmunológicos y Fisiopatológicos es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Frontiers in Medicine es
sedici.relation.journalVolumeAndIssue vol. 4 es
sedici.rights.sherpa * Color: green * Pre-print del autor: si * Post-print del autor: si * Versión de editor/PDF:si * Condiciones: >>On open access repositories >>Authors retain copyright >>Creative Commons Attribution License >>Published source must be acknowledged with citation >>First publication by Frontiers Media must be acknowledged >>Publisher's version/PDF may be used >>Articles are placed in PubMed Central immediately on behalf of authors. >>All titles are open access journals >>Publisher last reviewed on 24/07/2019 * Link a Sherpa: http://sherpa.ac.uk/romeo/issn/2296-858X/es/


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)