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dc.date.accessioned 2020-06-08T18:13:41Z
dc.date.available 2020-06-08T18:13:41Z
dc.date.issued 2008
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/97756
dc.description.abstract The aim of this study was to assess the induction of structural chromosomal aberrations in peripheral blood lymphocytes of malnourished and eutrophic children with bacterial infections. Thirty-six infants concurrent to the Hospital Interzonal de Agudos y Crónicos Dr. Alejandro Korn, La Plata, Argentina were included in this analysis; 11 infected and malnourished (IM), 7 infected and eutrophic (IE) and 18 non-infected and eutrophic (NE). Children aged 1-60 months. Anthropometric and clinic evaluation were performed to assess nutritional condition. We scored structural chromosome aberrations (SCA) in 100 metaphases per individual. Statistical analysis was performed by the Epi Dat 3.0 (OPS-OMS, 2003), through «Test de Diferencias entre dos proporciones muestrales» (p<0.05). Total SCE frequency was five times higher in IM children than that of IE ones (15,1% vs. 3,33% p<0,001) and two times greater in IE than in NE children (3,33% vs. 1,88% p<0.05). Results presented here showed an increase frequency of SCA not only in relation with malnutrition but also with the presence of bacterial infections. It is difficult to discern whether structural chromosome aberrations are due to malnutrition per se, bacterial or viral infections, antibiotics or all of these factors acting on malnourished tissues. In conclusion, mutagenic factors cause chromosomal changes more easily in an altered environment. en
dc.format.extent 15-20 es
dc.language en es
dc.subject Protein energy malnutrition es
dc.subject Bacterial infections es
dc.subject Structural chromosome aberrations es
dc.subject Children es
dc.subject Genética es
dc.title Chromosomal effects of infections in malnourished and eutrophic children of Gran La Plata en
dc.type Articulo es
sedici.identifier.uri https://ri.conicet.gov.ar/11336/83515 es
sedici.identifier.other hdl:11336/83515 es
sedici.identifier.issn 1666-0390 es
sedici.creator.person Padula, Gisel es
sedici.creator.person Seoane, Analía Isabel es
sedici.subject.materias Biología es
sedici.subject.materias Ciencias Naturales es
sedici.description.fulltext true es
mods.originInfo.place Instituto de Genética Veterinaria es
mods.originInfo.place Facultad de Ciencias Naturales y Museo es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Argentina (CC BY-NC-SA 2.5)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/2.5/ar/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Basic and Applied Genetics es
sedici.relation.journalVolumeAndIssue vol. 19, no. 1 es

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Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Argentina (CC BY-NC-SA 2.5) Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Argentina (CC BY-NC-SA 2.5)