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dc.date.accessioned 2020-06-12T19:09:47Z
dc.date.available 2020-06-12T19:09:47Z
dc.date.issued 2013-07-07
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/98211
dc.description.abstract Mu Opioid Receptor (MOR) activation by exogenous or endogenous agonists causes reduction of pain threshold after a noxious stimulus, relieving pain sensation.MOR is encoded by OPRM1 gene and its messenger RNA suffers extensible modifications by alternative splicing and single nucleotide polymorphisms (SNPs). A118G (N40D) is the most frequent encoding MOR SNP in humans. In this review we discuss the impact of this polymorphism at molecular, cellular and clinical levels. Since some SNPs are unequally distributed among human populations, we also discuss the utility of A118G as an ethnicity marker among worldwide human populations. As an example, we evaluate A118G frequency in an Argentinean humanpopulation and compare it with worldwide frequencies extracted from HapMap database. en
dc.format.extent 1-6 es
dc.language en es
dc.subject Mu-opioid receptor es
dc.subject A118g polymorphism es
dc.subject N40d polymorphism es
dc.subject Voltage-gated calcium channel es
dc.subject Population studies es
dc.title Impact of A118G polymorphism on the Mu opioid receptor function in pain en
dc.type Articulo es
sedici.identifier.uri https://ri.conicet.gov.ar/11336/85028 es
sedici.identifier.uri https://www.omicsonline.org/open-access/impact-of-ag-polymorphism-on-the-mu-opioid-receptor-function-in-pain-2167-0846.1000119.php?aid=15830 es
sedici.identifier.other http://dx.doi.org/10.4172/2167-0846.1000119 es
sedici.identifier.other hdl:11336/85028 es
sedici.identifier.issn 2167-0846 es
sedici.creator.person López Soto, Eduardo Javier es
sedici.creator.person Agosti, Francina es
sedici.creator.person Catanesi, Cecilia Inés es
sedici.creator.person Raingo, Jesica es
sedici.subject.materias Medicina es
sedici.description.fulltext true es
mods.originInfo.place Instituto Multidisciplinario de Biología Celular es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Journal of Pain & Relief es
sedici.relation.journalVolumeAndIssue vol. 2, no. 2 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution 4.0 International (CC BY 4.0)