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dc.date.accessioned 2020-06-22T13:24:04Z
dc.date.available 2020-06-22T13:24:04Z
dc.date.issued 2011-05
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/98702
dc.description.abstract Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals. en
dc.format.extent 374-377 es
dc.language en es
dc.subject Benznidazole es
dc.subject Rat blood es
dc.subject Chagas disease es
dc.subject HPLC es
dc.title Benznidazole levels in blood vary with age in rats en
dc.type Articulo es
sedici.identifier.uri https://ri.conicet.gov.ar/11336/24892 es
sedici.identifier.uri https://memorias.ioc.fiocruz.br/article/144/benznidazole-levels-in-blood-vary-with-age-in-rats es
sedici.identifier.other http://dx.doi.org/10.1590/S0074-02762011000300021 es
sedici.identifier.other hdl:11336/24892 es
sedici.identifier.issn 1678-8060 es
sedici.creator.person Bulffer, Romina Fernanda es
sedici.creator.person Castro, José Alberto es
sedici.creator.person Fanelli, Silvia Laura es
sedici.subject.materias Zoología es
sedici.description.fulltext true es
mods.originInfo.place Instituto de Limnología "Dr. Raúl A. Ringuelet" es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Memórias do Instituto Oswaldo Cruz es
sedici.relation.journalVolumeAndIssue vol. 106, no. 3 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)