Santa Cruz province is the second largest province in Argentina, and also the least populated. !is province makes up the southern tip of continental Argentina. Althought it has low population density and is remote from big cities, in the past it received well-deserved attention from researchers. !is was probably due to the presence of many interesting species, among them some threatened, with taxonomic singularities, and/or endemism. !e goal of this work is to update knowledge of the distribution and natural history of 21 species from Santa Cruz, including five new to the province.