Upload resources

Upload your works to SEDICI to increase its visibility and improve its impact

 

Show simple item record

dc.date.accessioned 2020-09-10T16:28:49Z
dc.date.available 2020-09-10T16:28:49Z
dc.date.issued 2015-02
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/104347
dc.description.abstract Arsenic (As) is one of the most toxic naturally occurring contaminants in the environment. The major source of human exposure to inorganic As (iAs) is through contaminated drinking water. Although both genotoxicity and carcinogenicity derived from this metalloid have been thoroughly studied, the effects of iAs on the development and function of the central nervous system (CNS) have received less attention and only a few studies have focused on neurobehavioral effects. Thus, in order to characterize developmental and behavioral alterations induced by iAs exposure, pregnant Wistar rats were exposed to 0.05 and 0.10 mg/L iAs through drinking water during gestation and lactation. Sensory-motor reflexes in each pup were analyzed and the postnatal day when righting reflex, cliff aversion and negative geotaxis were observed was recorded. Functional Observational Battery (FOB) and locomotor activity in an open field were assessed in 90-day-old offspring. Results show that rats exposed to low iAs concentrations through drinking water during early development evidence a delay in the development of sensory-motor reflexes. Both FOB procedure and open-field tests showed a decrease in locomotor activity in adult rats. This study reveals that exposure to the above-mentioned iAs concentrations produces dysfunction in the CNS mechanisms whose role is to regulate motor and sensory development and locomotor activity.
dc.language en es
dc.subject Arsenic es
dc.subject Development exposure es
dc.subject Sensory-motor reflexes es
dc.subject Functional observational battery es
dc.subject Locomotor activity es
dc.subject Rat es
dc.title Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation en
dc.type Articulo es
sedici.identifier.uri http://hdl.handle.net/11336/7590 es
sedici.identifier.other https://doi.org/10.1016/j.ntt.2015.02.005 es
sedici.identifier.other hdl:11336/7590 es
sedici.identifier.issn 0892-0362 es
sedici.creator.person Gumilar, Fernanda Andrea es
sedici.creator.person Lencinas, Ileana es
sedici.creator.person Bras, Cristina Liliana es
sedici.creator.person Giannuzzi, Leda es
sedici.creator.person Minetti, Alejandra es
sedici.subject.materias Química es
sedici.subject.materias Biología es
sedici.description.fulltext true es
mods.originInfo.place Centro de Investigación y Desarrollo en Criotecnología de Alimentos es
sedici.subtype Preprint es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Neurotoxicology and Teratology es
sedici.relation.journalVolumeAndIssue vol. 49 es


Download Files

This item appears in the following Collection(s)

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)