Cases of pigmentary abnormalities have been documented in several amphibians and reptiles. These abnormalities have been classified as leucism, albinism, melanism and axanthism, among others. We report here the first case of axanthism in the frog Smilisca baudinii, as well as in the entire corresponding genus. To our knowledge, it is also the first report of axanthism in wild amphibians from Mexico.