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dc.date.accessioned 2021-10-07T18:29:59Z
dc.date.available 2021-10-07T18:29:59Z
dc.date.issued 2020-02-26
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/126417
dc.description.abstract Background: The role intestinal epithelial cells (IECs) play in the breakdown of tolerance to gluten at an early stage in celiac disease (CeD) is unclear. Epithelial stress is a feature of CeD, and although the triggers are largely unknown, it is accompanied by expression of several markers that could be involved in initiation of inflammatory responses. IECs have been shown to express MHC class II (MHC-II) molecules and participate in antigen presentation in several models. Whether IECs can participate in gluten peptide presentation, the major environmental trigger in celiac disease, is unknown. To study this, a model expressing human MHC-II, HLA DQ8 or HLADQ2, would be required. Aims: To develop organoid monolayers from transgenic mice expressing human celiac risk genes: HLA-DQ8 and -DQ2. To investigate conditions leading to the induction of epithelial MHC-II and its main co-stimulatory molecules, CD80, CD86 and CD40, that could enable early gluten peptide presentation. en
dc.format.extent 73-74 es
dc.language en es
dc.subject intestinal epithelial cells es
dc.subject celiac disease es
dc.title Humanized celiac-prone epithelium in vitro express MHC-II and co-stimulatory molecules necessary for gluten peptide presentation en
dc.type Articulo es
sedici.identifier.other doi:10.1093/jcag/gwz047.199 es
sedici.identifier.issn 2515-2084 es
sedici.identifier.issn 2515-2092 es
sedici.creator.person Rahmani, Sara es
sedici.creator.person Galipeau, Heather J. es
sedici.creator.person Su, Hsuan-Ming es
sedici.creator.person Chirdo, Fernando Gabriel es
sedici.creator.person Didar, Tohid F. es
sedici.creator.person Verdu, Elena F. es
sedici.subject.materias Ciencias Exactas es
sedici.description.fulltext true es
mods.originInfo.place Instituto de Estudios Inmunológicos y Fisiopatológicos es
sedici.subtype Comunicacion es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.workflowEdited true es
sedici.relation.journalTitle Journal of the Canadian Association of Gastroenterology es
sedici.relation.journalVolumeAndIssue vol. 3, no. Supplement_1 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)