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dc.date.accessioned 2022-03-23T12:43:20Z
dc.date.available 2022-03-23T12:43:20Z
dc.date.issued 2009-12-11
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/133155
dc.description.abstract Methimazole (MeimzH) is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)2(NO3)2].0.5H2O and [Cu(MeimzH)2(H2O)2](NO3)2·H2O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated. en
dc.format.extent 255-264 es
dc.language en es
dc.subject Methimazole es
dc.subject Copper es
dc.subject Biometals es
dc.subject Grave’s disease es
dc.subject EPR es
dc.subject FTIR es
dc.subject UV-visible es
dc.subject ALP inhibition es
dc.title Copper(II) complexes of methimazole, an anti Grave’s disease drug en
dc.type Articulo es
sedici.identifier.other doi:10.1007/s10534-009-9283-7 es
sedici.identifier.other pmid:20012553 es
sedici.identifier.issn 1572-8773 es
sedici.identifier.issn 0966-0844 es
sedici.title.subtitle Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor en
sedici.creator.person Urquiza, Nora M. es
sedici.creator.person Manca, Silvia G. es
sedici.creator.person Moyano, María Alejandra es
sedici.creator.person Dellmans, Raquel Arrieta es
sedici.creator.person Lezama, Luis es
sedici.creator.person Rojo, Teófilo es
sedici.creator.person Naso, Luciana Gissella es
sedici.creator.person Williams, Patricia Ana María es
sedici.creator.person Ferrer, Evelina Gloria es
sedici.subject.materias Química es
sedici.description.fulltext true es
mods.originInfo.place Centro de Química Inorgánica es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Biometals es
sedici.relation.journalVolumeAndIssue vol. 23, no. 2 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution 4.0 International (CC BY 4.0)