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dc.date.accessioned 2022-11-02T15:50:45Z
dc.date.available 2022-11-02T15:50:45Z
dc.date.issued 2016-03
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/145015
dc.description.abstract Cardiovascular disease (CVD) is a major cause of disability and premature death throughout the world. Diets with antithrombotic components offer a convenient and effective way of preventing and reducing CVD incidence. The aim of the present work was to assess in vivo and ex vivo effects of Amaranthus hypochondriacus proteins on platelet plug formation and coagulation cascade. Amaranth proteins were orally administrated to rats (AG, 8 animals) and bleeding time was determined showing no significant difference compared with control rats (CG, 7 animals). However, results show a strong tendency, suggesting that amaranth proteins are involved in the inhibition of thrombus formation. Non-anticoagulated blood extracted from animals was analyzed with the hemostatometer, where AG parameters obtained were twice the values showed by CG. The clotting tests, thrombin time (TT) and activated partial thromboplastin time (APTT), presented a 17 and 14% clotting formation increase respectively when comparing AG with CG. The ex-vivo assays confirm the hypothesis inferring that amaranth proteins are a potential antithrombotic agent. en
dc.format.extent 19-27 es
dc.language en es
dc.subject Functional food es
dc.subject Amaranth proteins es
dc.subject Antithrombotic activity es
dc.subject Animals assays es
dc.title Antithrombotic Effects of Amaranthus hypochondriacus Proteins in Rats en
dc.type Articulo es
sedici.identifier.other doi:10.1007/s11130-015-0517-2 es
sedici.identifier.other pmid:26627100 es
sedici.identifier.issn 1573-9104 es
sedici.identifier.issn 0921-9668 es
sedici.creator.person Sabbione, Ana Clara es
sedici.creator.person Rinaldi, Gustavo es
sedici.creator.person Añón, María Cristina es
sedici.creator.person Scilingo, Adriana Alicia es
sedici.subject.materias Ciencias Exactas es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Centro de Investigación y Desarrollo en Criotecnología de Alimentos es
mods.originInfo.place Centro de Investigaciones Cardiovasculares es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Plant Foods for Human Nutrition es
sedici.relation.journalVolumeAndIssue vol. 71, no. 1 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution 4.0 International (CC BY 4.0)