Modificaciones electrolíticas durante el coma post convulsivo

Abstract

Las alteraciones electrolíticas que sobrevienen durante la epilepsia o durante las convulsiones experimentales, han sido motivo de diversas investigaciones tendientes a establecer relaciones entre el mecanismo de producción de los ataques y los desequilibrios iónicos de] plasma y de los tejidos. Los estudios en cuestión han puesto en evidencia los trastornos, sobre todo del metabolismo del potasio y del fósforo, elementos que desde otro punto de vista han sido considerados por distintos investigadores como agentes causantes de los estados de shock en distintas circunstancias clínicas y experimentales.

The coma, which causes intense convulsions in the dog and which are provoked by electric cerebral excitation or by cardiazol, coincides with a constant and remarkable increase of potassium and of total acid soluble phosphorus of the plasma. Whilst coma state coincides with the maximum concentration of potasium which decreases parallelly while the animal recovers himself, total acid-soluble phosphorus generally gets its highest power when the animal made his total recovery. On account of the close relation between potassium plasmatic cooncentration and the animal recovery, potassium would be the toxic agent and the causer of post-convulsive depression. Animals which die following convulsions, show a little before death the most remarkable increase of potassium and plasmatic phosphorus. Potassium and phosphorus increase is determined by tissues anoxia which produces respiratory muscles contracture and inhibition of the centres and also by muscular contractions and nervous centres excitation. We find the most remarkable potassium increase in the suprahcpatic vein, because the separation of these ions on excited liver side is very great.