Diabetic neuropathy is a disease that affects a large proportion of the world population, so that its prevention and early detection is of vital importance at the present time. In this paper we evaluate an ANN and SVM designed using MatLab 7.9.0.529 for the classification and prediction of patients with diabetic neuropathy, using Pulse Waves Sequences of Blood Volume. Efficiency was evaluated taking into account the algorithms and training time as well as effectiveness in classification and prediction. Considering 40 cases in the process of learning and 18 in the validation, the best classification results were obtained with the ANN for an 88.88% effective with the Gradient descent learning algorithm with adaptive learning rate, and the SVM was obtained 72.22% success rate using the Quadratic programming algorithm. In predicting both methods were 100% effective.