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Mostrar el registro sencillo del ítem 2014-06-25T22:06:56Z 2014-06-25T22:06:56Z 2003-09-18
dc.description.abstract Background: Hyperhomocysteinemia and lipid abnormalities are commonly found in patients with chronic renal failure; both are recognized as risk factors for atherosclerosis. The homocysteine-lowering effect of pyridoxine is controversial. This study was performed to determine the effect of a high dose of pyridoxine (300 mg i.v. three times a week) on plasma and red blood cell lipid profile and plasma homocysteine concentration in twelve chronic renal failure patients on regular hemodialysis. Fasting blood samples were taken at the beginning of the study (basal 1), after 30 and 60 days of treatment and 4 months after withdrawal (basal 2). Results: Pyridoxine supplementation induced a significant decrease in total plasma homocysteine level and also a lowering effect in plasma total cholesterol and triglycerides. These biochemical data increased when the samples were taken at basal 2, reaching the levels obtained at the beginning of the experiment. LDL cholesterol increased whereas HDL cholesterol was reduced during the treatment. In erythrocyte membranes vitamin B6 therapy enhanced the cholesterol/phospholipid ratio as well as the fluorescence anisotropy of diphenyl-hexatriene. Conclusions: We conclude that high doses of pyridoxine represent an effective strategy to ameliorate both plasma homocysteine levels and lipid profiles in chronic renal failure patients, protecting them from atherosclerosis. Further research using a long-term treatment would be necessary in an attempt to restore the fatty acid pattern and the fluidity of red cell membranes. en
dc.format.extent p. 1-6 es
dc.language en es
dc.title Variations in the lipid profile of patients with chronic renal failure treated with pyridoxine en
dc.type Articulo es
sedici.identifier.uri es
sedici.identifier.doi 10.1186/1476-511X-2-1
sedici.identifier.issn 1476-511X es
sedici.creator.person Tacconi de Gómez Dumm, Nelva es
sedici.creator.person Giammona, Ana G. es
sedici.creator.person Touceda, Luis Alberto es
sedici.subject.materias Ciencias Exactas es
sedici.subject.materias Ciencias Médicas es
sedici.subject.other homocysteine en
sedici.subject.other membrane phospholipid en
sedici.subject.other pyridoxine en
sedici.subject.other triacylglycerol en
sedici.subject.other amino acid blood level en
sedici.subject.other anisotropy en
sedici.subject.other cell membrane fluidity en
sedici.subject.other erythrocyte membrane en
sedici.description.fulltext true es Facultad de Ciencias Exactas es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 3.0 Unported (CC BY 3.0)
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Lipids in Health and Disease es
sedici.relation.journalVolumeAndIssue vol. 2 es

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Creative Commons Attribution 3.0 Unported (CC BY 3.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution 3.0 Unported (CC BY 3.0)