Emblica officinalis reduces the initiation of oxidative stress by salmonella typhimurium in mice and can be used in typhoid

Abstract

Typhoid fever remains an important cause of illness globally with the annual incidence at 21 million cases, of which many end fatally. Due to increasing resistant to antibiotics and limited available vaccine against salmonella, the requirement is to explore the plant products against this disease. Mice pretreated with lyophilized juice of Emblica oficinalis (EO) orally at a dose of 500 mg/kg (EO500) body weight for 20 and 30 days showed full protection against 1X100000 CFU and 2X100000 CFU of S. typhimurium respectively. Mice pretreated with EO500 for 30 days and then challenged with 50000 CFU of S. typhimurium intraperitonially showed reduced CAT and LPO activity by 6.8% and 98%, respectively and increased GSH activity by 67% as compared to saline infected control. The experimental data indicated that regular intake of EO inhibit the induction of oxidative stress by S. typhimurium in mice and may reduce the risk of getting typhoid fever.