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dc.date.accessioned 2010-05-05T19:07:58Z
dc.date.available 2010-05-05T03:00:00Z
dc.date.issued 2010 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/7925
dc.description.abstract Diabetes mellitus (DM) is a serious health problem affecting millions of individuals worldwide. It is showed that some changes of many enzymes and transporters concerned with metabolism and disposal of drug have taken place in organism under pathologic state of DM. The pharmacokinetic of drug should be different between diabetic and normal animals. Rutin and quercetin can also be used to treatment of diabetic mellitus. So, this paper investigated the difference of pharmacokinetic profiles of rutin and quercetin in diabetic and normal rats in vivo by HPLC-DAD method. The pharmacokinetic parameters were analyzed by double-compartmental method (DAS2.0). The pharmacokinetic parameters of rutin in normal and diabetic rats were: (22.203 ± 2.6) and (36.174 ± 7.5) mg · h/L for AUC(0-4); (0.726 ± 0.13) and (1.069 ± 0.17) h for MRT(0-4), (5.413 ± 0.57) and (6.595 ± 0.38) h for t1/2; (0.424 ± 0.071) and (0.226 ± 0.072) L/h/kg for Cl, respectively. The pharmacokinetic parameters of quercetin in normal and diabetic rats were: (5.243 ± 0.82) and (2.376 ± 0.61) mg h/L for AUC(0-4); (2.556 ± 0.52) and (1.616 ± 0.35) h for MRT(0-4), (1.216 ± 0.17) and (0.992 ± 0.12) h for t1/2; (1.918 ± 0.32) and (4.342 ± 0.99) L/h/kg for Cl, respectively. Those results indicate that the pharmacokinetic profiles of rutin and quercetin were changed by DM. es
dc.format.extent 408-414 es
dc.language en es
dc.subject Farmacología es
dc.subject diabetes mellitus; high performance liquid chromatography; pharmacokinetic; rutin; Quercetin es
dc.subject Diabetes Mellitus es
dc.subject Farmacocinética es
dc.title Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_1_12.pdf es
sedici.creator.person Tang, Daoquan es
sedici.creator.person Gao, Yuanyuan es
sedici.creator.person Tang, Anbang es
sedici.creator.person Chen, Yonggang es
sedici.creator.person Wei, Yaqin es
sedici.creator.person Yin, Xiaoxin es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001411 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 29, no. 3 es

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