Diabetes mellitus (DM) is a serious health problem affecting millions of individuals worldwide.
It is showed that some changes of many enzymes and transporters concerned with metabolism and
disposal of drug have taken place in organism under pathologic state of DM. The pharmacokinetic of drug
should be different between diabetic and normal animals. Rutin and quercetin can also be used to treatment
of diabetic mellitus. So, this paper investigated the difference of pharmacokinetic profiles of rutin
and quercetin in diabetic and normal rats in vivo by HPLC-DAD method. The pharmacokinetic parameters
were analyzed by double-compartmental method (DAS2.0). The pharmacokinetic parameters of rutin
in normal and diabetic rats were: (22.203 ± 2.6) and (36.174 ± 7.5) mg · h/L for AUC(0-4); (0.726 ± 0.13)
and (1.069 ± 0.17) h for MRT(0-4), (5.413 ± 0.57) and (6.595 ± 0.38) h for t1/2; (0.424 ± 0.071) and (0.226 ±
0.072) L/h/kg for Cl, respectively. The pharmacokinetic parameters of quercetin in normal and diabetic
rats were: (5.243 ± 0.82) and (2.376 ± 0.61) mg h/L for AUC(0-4); (2.556 ± 0.52) and (1.616 ± 0.35) h for
MRT(0-4), (1.216 ± 0.17) and (0.992 ± 0.12) h for t1/2; (1.918 ± 0.32) and (4.342 ± 0.99) L/h/kg for Cl, respectively.
Those results indicate that the pharmacokinetic profiles of rutin and quercetin were changed by
DM.