Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system

Abstract

The self-microemulsifying drug delivery system (SMEDDS) was employed to improve the bioavailability of sulpiride, a drug which is poorly soluble. The mean droplet size and emulsification time of the test formulation used for in vivo study were 9.27 ± 2.02 nm and 87 ± 5 s, respectively. When compared with Reference (Dogmatil®), the test formulation exhibited faster in-vitro drug release rate. The Cmax and AUC values of the test formulation were significantly higher than those of Reference, with an enhancement of 210.64% in the extent of absorption in rabbits. In conclusion, SMEDDS could be a potential drug delivery system to enhance the bioavailability of sulpiride.