Synthesis and pharmacological study of some novel thiazolidinones

Abstract

A series of some novel thiazolidinones derivatives were synthesized and evaluated for their pharmacological activities. Thiazolidinones were synthesized from p-nitro aniline in four steps. First Schiff’s bases (V1- 8) were prepared by reacting the N4 -(4-nitrophenyl) thiazole-2,4-diamine (3) of p-nitro aniline derivatives with different aromatic aldehydes. Cyclocondensation of the Schiff’s bases with thioglycolic acid in presence of anhydrous zinc chloride resulted in the formation of the corresponding thiazolidinone (VD1-8) analogues. The structures of the newly synthesized compounds have been established on the basis of their spectral data. The synthesized selected compounds were evaluated for their anti-inflammatory and analgesic activity.