Time-dependent and concentration -dependent upregulation of carbamazepine efflux transporter: a preliminary assessment from salivary drug monitoring

Maldonado, Cecilia; Fagiolino, Pietro; Vázquez, Marta; Eiraldi, Rosa; Alvariza, Silvana; Bentancur, Camilo; Álvarez, Pablo

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Time-dependent and concentration -dependent upregulation of carbamazepine efflux transporter: a preliminary assessment from salivary drug monitoring

2011

Tipo de documento: Articulo

Resumen

The aim of the present study was to detect efflux transporter induction at salivary glands. Six healthy volunteers were involved. On the first day subjects received a single carbamazepine (CBZ) dose of 400 mg. Couples of salivary samples (first and second fraction, S1 and S2) were collected throughout time after dosing. The following 6 days subjects received 200 mg every twelve hours, and morning pre-dose samples were collected.