We assessed to response of larvae of the golden mussel (Limnoperna fortunei) to different concentrations of a quaternary ammonium polymer (Bulab 6002 ®) in order to estimate its effectiveness in controlling this invasive mussel. Mussels were collected along the coast of the Rio de la Plata, Argentina, and were tested in two laboratory trials. The estimated median lethal concentration for these 24-h exposures were 9.6 mg/L and 4, 6 mg/L, indicating that this biocide may be suitable as a control agent for this mussel.