First, I want to clarify for Dr. Guiso that in no part of our paper did we state that “the vaccines are not protecting against new circulating isolates.” Therefore, I recommend a more careful reading of our work in order to determine the true subject under discussion. My colleagues and I will not argue about what is not stated in the article. On the other hand, it is important to point out that all protection results presented in our paper were obtained using mice, and thus, care in making extrapolations to humans must be taken.