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dc.date.accessioned 2019-10-15T16:39:31Z
dc.date.available 2019-10-15T16:39:31Z
dc.date.issued 2003
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/83288
dc.description.abstract Pertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity. Opsonophagocytosis was recently found to play a central role in cellular bactericidal activity against B. pertussis. In the present study, we studied the specificity of opsonic antibodies. Anti-pertactin antibodies, but not anti-pertussis toxin, anti-fimbriae, or anti-filamentous hemagglutinin antibodies, were found to be crucial for B. pertussis phagocytosis. These data are consistent with field studies showing that levels of antibodies to pertactin correlate with protection. en
dc.format.extent 738-742 es
dc.language en es
dc.subject Bordetella pertussis es
dc.title Crucial role of antibodies to pertactin in Bordetella pertussis immunity en
dc.type Articulo es
sedici.identifier.other doi:10.1086/377283 es
sedici.identifier.other eid:2-s2.0-0141724579 es
sedici.identifier.issn 0022-1899 es
sedici.creator.person Hellwig, Sandra M. M. es
sedici.creator.person Rodríguez, María Eugenia es
sedici.creator.person Berbers, Guy A. M. es
sedici.creator.person Winkel, Jan G. J. van de es
sedici.creator.person Mooi, Frits R. es
sedici.subject.materias Ciencias Exactas es
sedici.description.fulltext true es
mods.originInfo.place Centro de Investigación y Desarrollo en Fermentaciones Industriales es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.workflowEdited true es
sedici.relation.journalTitle Journal of Infectious Diseases es
sedici.relation.journalVolumeAndIssue vol. 188, no. 5 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)