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dc.date.accessioned 2019-10-15T17:05:10Z
dc.date.available 2019-10-15T17:05:10Z
dc.date.issued 2007
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/83297
dc.description.abstract Symptomatic hypogammaglobulinaemia in children younger than 2 years of age was studied to rule out a primary immunodeficiency. Thirty-four patients were referred to the Immunology Service to study the hypogammaglobulinaemia- associated clinical picture. Food allergy was documented in 10 patients by personal and familial history, presence of specific immunoglobulin E (IgE) and elevated total serum IgE levels. Coeliac disease and human immunodeficiency virus infection were also ruled out. Protein loss through stools was assessed by clearance of α1-antitrypsin (AAT). Serum immunoglobulin levels were determined by nephelometry and functional antibodies were studied by enzyme-linked immunosorbent assay. The cellular immune response was assessed by in vitro lymphocyte proliferation in response to mitogens and cell subsets were analysed by flow cytometry. In five patients of the 10 patients we suspected a protein loss through the mucosa. Four of these five patients showed an increased AAT and the other showed an extensive cutaneous lesion. Immunological studies revealed normal antibody function, in vitro lymphoproliferative responses and cell numbers in four of the 5 patients. One patient showed abnormally low numbers of CD4+ T cells as well as a defective proliferative response to mitogens. After diagnosis of cow milk allergy, milk was replaced with infant milk formula containing hydrolysed proteins. Recovery of immunoglobulin values and clinical resolution were achieved. Hypogammaglobulinaemia during early childhood in some children may be secondary to cow milk allergy, and immunoglobulins and cells may leak through the inflamed mucosa. Resolution of symptoms as well as normalization of immunoglobulin values may be easily achieved by avoidance of the offending allergen. en
dc.format.extent 140-146 es
dc.language en es
dc.subject Antibodies es
dc.subject Cows' milk es
dc.subject Food allergy es
dc.subject Immunodeficiency es
dc.subject Immunoglobulin E es
dc.title Hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age en
dc.type Articulo es
sedici.identifier.other doi:10.1111/j.1365-2567.2007.02628.x es
sedici.identifier.other eid:2-s2.0-34547685782 es
sedici.identifier.issn 0019-2805 es
sedici.creator.person Bezrodnik, Liliana es
sedici.creator.person Gómez Raccio, Andrea C. es
sedici.creator.person Canil, Laura M. es
sedici.creator.person Rey, María Amanda es
sedici.creator.person Carabajal, Patricia C. es
sedici.creator.person Fossati, Carlos Alberto es
sedici.creator.person Docena, Guillermo es
sedici.subject.materias Ciencias Exactas es
sedici.description.fulltext true es
mods.originInfo.place Laboratorio de Investigaciones del Sistema Inmune es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Immunology es
sedici.relation.journalVolumeAndIssue vol. 122, no. 1 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)