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dc.date.accessioned | 2019-10-18T17:55:26Z | |
dc.date.available | 2019-10-18T17:55:26Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/83633 | |
dc.description.abstract | The effect of progesterone (P4) on fructose rich diet (FRD) intake-induced metabolic, endocrine and parametrial adipose tissue (PMAT) dysfunctions was studied in the adult female rat. Sixty day-old rats were i.m. treated with oil alone (control, CT) or containing P4 (12 mg/kg). Rats ate Purina chow-diet ad libitum throughout the entire experiment and, between 100 and 120 days of age drank ad libitum tap water alone (normal diet; CT-ND and P4-ND) or containing fructose (10% w/v; CT-FRD and P4-FRD). At age 120 days, animals were subjected to a glucose tolerance test or decapitated. Plasma concentrations of various biomarkers and PMAT gene abundance were monitored. P4-ND (vs. CT-ND) rats showed elevated circulating levels of lipids. CT-FRD rats displayed high (vs. CT-ND) plasma concentrations of lipids, leptin, adiponectin and plasminogen activator inhibitor-1 (PAI-1). Lipidemia and adiponectinemia were high (vs. P4-ND) in P4-FRD rats. Although P4 failed to prevent FRD-induced hyperleptinemia, it was fully protective on FRD-enhanced plasma PAI-1 levels. PMAT leptin and adiponectin mRNAs were high in CT-FRD and P4-FRD rats. While FRD enhanced PMAT PAI-1 mRNA abundance in CT rats, this effect was absent in P4 rats. Our study supports that a preceding P4-enriched milieu prevented the enhanced prothrombotic risk induced by FRD-elicited high PAI-1 production. | en |
dc.format.extent | 1137-1150 | es |
dc.language | en | es |
dc.subject | Adipokines | es |
dc.subject | Allostasis | es |
dc.subject | Glucose tolerance | es |
dc.subject | High carbohydrate diet | es |
dc.subject | Insulin | es |
dc.title | Fructose rich diet-induced high plasminogen activator inhibitor-1 (PAI-1) production in the adult female rat: Protective effect of progesterone | en |
dc.type | Articulo | es |
sedici.identifier.other | doi:10.3390/nu4081137 | es |
sedici.identifier.other | eid:2-s2.0-84870362780 | es |
sedici.identifier.issn | 2072-6643 | es |
sedici.creator.person | Castrogiovanni, Daniel | es |
sedici.creator.person | Alzamendi, Ana | es |
sedici.creator.person | Ongaro Gambino, Luisina | es |
sedici.creator.person | Giovambattista, Andrés | es |
sedici.creator.person | Gaillard, Rolf C. | es |
sedici.creator.person | Spinedi, Eduardo | es |
sedici.subject.materias | Ciencias Exactas | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Instituto Multidisciplinario de Biología Celular | es |
mods.originInfo.place | Facultad de Ciencias Médicas | es |
mods.originInfo.place | Facultad de Ciencias Exactas | es |
sedici.subtype | Articulo | es |
sedici.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | Nutrients | es |
sedici.relation.journalVolumeAndIssue | vol. 4, no. 8 | es |
sedici.rights.sherpa | * Color: verde* Pre-print del autor: si* Post-print del autor: si* Versión de editor/PDF:si* Condiciones:>>En repositorios de acceso abierto>>La versión de editor/PDF puede utilizarse>>La fuente editorial debe reconocerse>>Creative Commons Attribution License 4.0>>Los autores conservan el copyright>>Se anima a los autores a enviar sus artículos publicados a los repositorios institucionales>>All titles are open access journals* Link a Sherpa: http://sherpa.ac.uk/romeo/issn/2072-6643/es/ |