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dc.date.accessioned 2019-10-25T15:38:57Z
dc.date.available 2019-10-25T15:38:57Z
dc.date.issued 2011
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/84083
dc.description.abstract Background: Enterocutaneous fistulae, pathological communications between the intestinal lumen and the abdominal skin, can arise as serious complication of gastrointestinal surgery. A current non-surgical treatment for this pathology involves topical application of sub-atmospheric pressure, also known as vacuum assisted closure (VAC). While this technique appears to be promising, surgeons report a number of cases in which its application fails to achieve fistula closure. Here, we evaluate the fistula's physical properties during the vacuum assisted closure process in a computational approach exploring the relevance of intraluminal intestinal pressure. Methods: A mathematical model formulated by differential equations based on tissue elasticity properties and principles of fluid mechanics was created and forcing functions were integrated to mimic intestinal pressure dynamics. A software to solve equations and to fit the model to experimentally obtained data was developed. This enabled simulations of vacuum assisted fistula closure under different intestinal pressure. Results: The simulation output indicates conditions, in which fistula closure can or cannot be expected suggesting favoured or impeded healing, respectively. When modifications of intestinal pressure, as observed in fistula accompanying pathologies, are integrated, the outcome of fistula closure changes considerably. Rise of intestinal pressure is associated with delay of fistula closure and temporary fistula radius augmentation, while reduction of intestinal pressure during sub-atmospheric pressure treatment contributes to a faster and direct fistula closure. Conclusion: From the model predictions, we conclude that administration of intestinal pressure decreasing compounds (e.g. butylscopolamine, glucagon) may improve VAC treatment, while intestinal pressure increasing drugs should be avoided. en
dc.format.extent 662-668 es
dc.language en es
dc.subject Computational model es
dc.subject Enterocutaneous fistula es
dc.subject Fistula radius es
dc.subject Intestinal pressure es
dc.subject Simulation es
dc.title Effect of intestinal pressure on fistula closure during vacuum assisted treatment: A computational approach en
dc.type Articulo es
sedici.identifier.other doi:10.1016/j.ijsu.2011.09.001 es
sedici.identifier.other eid:2-s2.0-83155175222 es
sedici.identifier.issn 1743-9191 es
sedici.creator.person Cattoni, Diego I. es
sedici.creator.person Ravazzola, Constanza es
sedici.creator.person Tüngler, Victoria es
sedici.creator.person Wainstein, Daniel E. es
sedici.creator.person Chara, Osvaldo es
sedici.subject.materias Ciencias Exactas es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Exactas es
mods.originInfo.place Instituto de Física de Líquidos y Sistemas Biológicos es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle International Journal of Surgery es
sedici.relation.journalVolumeAndIssue vol. 9, no. 8 es
sedici.rights.sherpa * Color: verde* Pre-print del autor: si* Post-print del autor: si* Versión de editor/PDF:no* Condiciones:>>Authors pre-print on any website, including arXiv and RePEC>>Author's post-print on author's personal website immediately>>Author's post-print on open access repository after an embargo period of between 12 months and 48 months>>Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months>>Author's post-print may be used to update arXiv and RepEC>>La versión de editor/PDF no puede utilizarse>>Debe enlazar a la versión de editor con DOI>>Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License>>Publisher last reviewed on 03/06/2015* Link a Sherpa: http://sherpa.ac.uk/romeo/issn/1743-9191/es/


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)