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dc.date.accessioned 2019-11-05T12:29:43Z
dc.date.available 2019-11-05T12:29:43Z
dc.date.issued 2000
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/84885
dc.description.abstract The native lactococcal plasmid pKR223 encodes two distinct phage resistance mechanisms, a restriction and modification (R/M) system designated LlaKR2I and an abortive infection mechanism (Abi) which affects prolate- headed-phage proliferation. The nucleotide sequence of a 16,174-bp segment of pKR223 encompassing both the R/M and Abi determinants has been determined, and sequence analysis has validated the novelty of the Abi system, which has now been designated AbiR. Analysis of deletion and insertion clones demonstrated that AbiR was encoded by two genetic loci, separated by the LlaKR2I R/M genes. Mechanistic studies on the AbiR phenotype indicated that it was heat sensitive and that it impeded phage DNA replication. These data indicated that AbiR is a novel multicomponent, heat-sensitive, 'early'- functioning Abi system and is the first lactococcal Abi system described which is encoded by two separated genetic loci. en
dc.format.extent 2647-2651 es
dc.language en es
dc.subject Lactococcus lactis es
dc.subject plasmid pKR223 es
dc.title Characterization of AbiR, a novel multicomponent abortive infection mechanism encoded by plasmid pKR223 of Lactococcus lactis subsp. lactis KR2 en
dc.type Articulo es
sedici.identifier.other doi:10.1128/AEM.66.6.2647-2651.2000 es
sedici.identifier.other eid:2-s2.0-0034097002 es
sedici.identifier.issn 0099-2240 es
sedici.creator.person Twomey, Denis P. es
sedici.creator.person Urraza, Patricio José de es
sedici.creator.person McKay, Larry L. es
sedici.creator.person O'Sullivan, Daniel J. es
sedici.subject.materias Ciencias Exactas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Exactas es
mods.originInfo.place Centro de Investigación y Desarrollo en Criotecnología de Alimentos es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Applied and Environmental Microbiology es
sedici.relation.journalVolumeAndIssue vol. 66, no. 6 es
sedici.rights.sherpa * RoMEO: amarillo* Pre-print del autor: can* Post-print del autor: restricted* Versión de editor/PDF:cannot* Condiciones:>>Author's pre-print on recognised non profit pre-print archives>>Author's post-print on funder's repositories, institutional repository or subject-based repositories, PubMed Central>>No comercial>>La versión de editor/PDF no puede utilizarse>>Publisher last contacted on 21/05/2015>>Publisher last reviewed on 13/02/2019* Link a Sherpa: http://sherpa.ac.uk/romeo/issn/0099-2240/es/


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)