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dc.date.accessioned 2019-11-08T16:25:45Z
dc.date.available 2019-11-08T16:25:45Z
dc.date.issued 2013
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/85241
dc.description.abstract Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology, both in neuronal and non-neuronal cells and tissues. Through negative feedback between intracellular Ca2+ and membrane voltage, BK channels provide a damping mechanism for excitatory signals. Molecular modulation of these channels by alternative splicing, auxiliary subunits and post-translational modifications showed that these channels are subjected to many mechanisms that add diversity to the BK channel ́ subunit gene. This complexity of interactions modulates BK channel gating, modifying the energetic barrier of voltage sensor domain activation and channel opening. Regions for voltage as well as Ca2+ sensitivity have been identified, and the crystal structure generated by the 2 RCK domains contained in the C-terminal of the channel has been described. The linkage of these channels to many intracellular metabolites and pathways, as well as their modulation by extracellular natural agents, has been found to be relevant in many physiological processes. This review includes the hallmarks of BK channel biophysics and its physiological impact on specific cells and tissues, highlighting its relationship with auxiliary subunit expression. en
dc.language en es
dc.subject Auxiliary subunits es
dc.subject BK channels es
dc.subject Diseases es
dc.subject Slo1 es
dc.subject Smooth muscle es
dc.subject Voltage sensor es
dc.title A BK (Slo1) channel journey from molecule to physiology en
dc.type Articulo es
sedici.identifier.other doi:10.4161/chan.26242 es
sedici.identifier.other eid:2-s2.0-84886994171 es
sedici.identifier.issn 1933-6950 es
sedici.creator.person Contreras, Gustavo F. es
sedici.creator.person Castillo, Karen es
sedici.creator.person Enrique, Nicolás Jorge es
sedici.creator.person Carrasquel Ursulaez, Willy es
sedici.creator.person Castillo, Juan Pablo es
sedici.creator.person Milesi, Verónica es
sedici.creator.person Neely, Alan es
sedici.creator.person Alvarez, Osvaldo es
sedici.creator.person Ferreira, Gonzalo es
sedici.creator.person Gonzalez, Carlos es
sedici.creator.person Latorre, Ramón es
sedici.subject.materias Ciencias Exactas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Exactas es
sedici.subtype Revision es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Channels es
sedici.relation.journalVolumeAndIssue vol. 7, no. 6 es
sedici.rights.sherpa * Color: green * Pre-print del autor: si * Post-print del autor: si * Versión de editor/PDF:si * Condiciones: >>Authors retain copyright >>Creative Commons Attribution License or Creative Commons Attribution Non-Commercial License available >>Publisher's version/PDF may be used >>Must link to publisher version >>Publisher copyright and source must be acknowledged with citation >>Article will be automatically deposited in subject-based repositories such as PubMed Central >>All titles are open access journals >>Publisher last contacted on 08/03/2012 * Link a Sherpa: http://sherpa.ac.uk/romeo/issn/1933-6950/es/


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)