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dc.date.accessioned 2019-11-28T15:20:44Z
dc.date.available 2019-11-28T15:20:44Z
dc.date.issued 2016
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/86271
dc.description.abstract Pharmacological treatment of Chagas disease with benznidazole (BNZ) is effective in children in all stages, but it is controversial in chronically infected adults. We report the pharmacokinetics and pharmacodynamics in six adult patients with Chagas disease treated with the new BNZ formulation (ABARAX®) in doses between 2.5-5.5 mg/Kg/ day. All but one patient had plasmatic BNZ concentrations within the expected range. All patients finalised treatment with nondetectable Trypanosoma cruzi quantitative polymerase chain reaction, which remained nondetectable at the six month follow-up. Our data suggests parasitological responses with the new BNZ and supports the hypothesis that treatment protocols with lower BNZ doses may be effective. en
dc.format.extent 218-221 es
dc.language en es
dc.subject Benznidazole es
dc.subject Chagas disease es
dc.subject Pharmacology es
dc.title Pharmacokinetic and pharmacodynamic responses in adult patients with chagas disease treated with a new formulation of benznidazole en
dc.type Articulo es
sedici.identifier.other doi:10.1590/0074-02760150401 es
sedici.identifier.other eid:2-s2.0-84960359436 es
sedici.identifier.issn 0074-0276 es
sedici.creator.person Fernández, Marisa Liliana es
sedici.creator.person Marson, María Elena es
sedici.creator.person Ramírez, Juan Carlos es
sedici.creator.person Mastrantonio Garrido, Guido Enrique es
sedici.creator.person Schijman, Alejandro Gabriel es
sedici.creator.person Altcheh, Jaime es
sedici.creator.person Riarte, Adelina Rosa es
sedici.creator.person García Bournissen, Facundo es
sedici.subject.materias Biología es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Exactas es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Memorias do Instituto Oswaldo Cruz es
sedici.relation.journalVolumeAndIssue vol. 111, no. 3 es
sedici.rights.sherpa * Color: gray * Pre-print del autor: unknown * Post-print del autor: unknown * Versión de editor/PDF:unknown * Condiciones: >>This publisher's policies have not been checked by Color. >>DOAJ says it is an open access journal, but this may only mean that it is freely available to read. >>Most open access publishers also permit self-archiving and re-use, but some do not. >>Do not assume that self-archiving is allowed, unless it is published under a Creative Commons license. >>Please contact the publisher for further information if necessary >>Email romeo@jisc.ac.uk if you wish to suggest adding this publisher properly to Color. * Link a Sherpa: http://sherpa.ac.uk/romeo/issn/0074-0276/es/


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Creative Commons Attribution 4.0 International (CC BY 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution 4.0 International (CC BY 4.0)