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dc.date.accessioned 2019-12-03T13:52:06Z
dc.date.available 2019-12-03T13:52:06Z
dc.date.issued 2016
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/86630
dc.description.abstract Purpose. Reactive oxygen species (ROS) are generated as an indirect product of radiation therapy (RT). Genetic variation in genes related to ROS metabolism may influence the level of RT-induced adverse effects. We evaluated the potential association of single nucleotide polymorphism (SNP)-related response to radiotherapy injury in breast cancer patients undergoing RT. Materials and Methods. Eighty patients receiving conventional RT were included. Acute effects were evaluated according to the Radiation Therapy Oncology Group (RTOG) scores. DNA was extracted from blood and buccal swab samples. SNPs were genotyped for GSTP1, GSTA1, SOD2, and NOS3 genes by polymerase chain reaction-based restriction fragment length polymorphism. Univariate analysis (odds ratios [ORs] and 95% confidence interval [CI]) and principal component analysis were used for correlation of SNPs and factors related to risk of developing ≥ grade 2 acute effects. Results. Sixty-five patients (81.2%) showed side effects, 32 (40%) presented moderate to severe acute skin toxicity, and 33 (41.2%) manifested minimal acute skin reactions by the end of treatment. In both univariate and multivariate analyses, nominally significant associations were found among body mass index (OR, 3.14; 95% CI, 8.5338 to 1.1274; p=0.022), breast size (OR, 5.11; 95% CI, 17.04 to 1.54; p=0.004), and grade ≥ 2 acute radiation skin toxicity. A significant association was also observed between NOS3 G894T polymorphism (OR, 9.8; 95% CI, 211.6 to 0.45; p=0.041) and grade ≥ 2 acute radiation skin toxicity in patients with neo-adjuvant chemotherapy treatment. Conclusion. The analysis of the factors involved in individual radiosensitivity contributed to the understanding of the mechanisms underlying this trait. en
dc.format.extent 948-954 es
dc.language en es
dc.subject Acute toxicity es
dc.subject Breast neoplasm es
dc.subject Oxidative stress es
dc.subject Radiation tolerance es
dc.subject Radiotherapy es
dc.subject Single nucleotide polymorphism es
dc.title Polymorphic variants in oxidative stress genes and acute toxicity in breast cancer patients receiving radiotherapy en
dc.type Articulo es
sedici.identifier.other doi:10.4143/crt.2015.360 es
sedici.identifier.other eid:2-s2.0-84981332492 es
sedici.identifier.issn 1598-2998 es
sedici.creator.person Córdoba, Elisa Eugenia es
sedici.creator.person Abba, Martín Carlos es
sedici.creator.person Lacunza, Ezequiel es
sedici.creator.person Fernández, Eduardo es
sedici.creator.person Güerci, Alba Mabel es
sedici.subject.materias Ciencias Exactas es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Exactas es
mods.originInfo.place Facultad de Ciencias Médicas es
mods.originInfo.place Instituto de Genética Veterinaria es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Cancer Research and Treatment es
sedici.relation.journalVolumeAndIssue vol. 48, no. 3 es
sedici.rights.sherpa * Color: gray * Pre-print del autor: unknown * Post-print del autor: unknown * Versión de editor/PDF:unknown * Condiciones: >>This publisher's policies have not been checked by Color. >>Please contact the publisher for further information if necessary * Link a Sherpa: http://sherpa.ac.uk/romeo/issn/1598-2998/es/


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Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)