In this paper, we present a new model of an artificial
immune system (AIS), based on the process
that suffers the T-Cell, it is called T-Cell
Model. It is used for solving constrained (numerical)
optimization problems. The model operates
on three populations: Virgins, Effectors and
Memory. Each of them has a different role. Also,
the model dynamically adapts the tolerance factor
in order to improve the exploration capabilities
of the algorithm. We also develop a new
mutation operator which incorporates knowledge
of the problem. We validate our proposed approach
with a set of test functions taken from
the specialized literature and we compare our results
with respect to Stochastic Ranking (which
is an approach representative of the state-of-theart
in the area), with respect to an AIS previously
proposed and a self-organizing migrating
genetic algorithm for constrained optimization
(C-SOMGA)