Natural products have been used for medicinal purposes for years. There is a growing interest in dental research to study the effect of plant derivatives on tooth enamel, both to avoid dissolution and to promote its remineralization. Studies performed using a grape seed extract on artificial enamel caries have shown the remineralizing effect of some organic compounds contained in the seed. Sesame seed is highly valued for its nutritional properties [3] however; there is insufficient information on the effect of its components on the demineralized dental enamel. Therefore, the objective of the work was the mechanical, morphological and topographic characterization of the dental enamel treated with a sesame solution, applying a cyclized regime, using artificial saliva as a conservation medium.