The Cavβ1 Subunit Regulates Gene Expression in Muscle Progenitor Cells

Abstract

CaVβ subunits are traditionally considered constituents of CaV complexes (CaV1or2, CaVβ, and CaV α2/δ), where they localize at the plasma membrane and serve to regulate channel expression and gating properties. Recent publications also show CaVβ subunit localization in the nucleus. This phenomenon has been observed under a variety of conditions (different cell types, β subunit isoforms, co-expressed proteins, etc). However, the mechanisms responsible for CaVβ subunit nuclear shuttling, as well as a physiological role for this nuclear localization, remain major questions.