An unhealthy diet, consisting mainly of saturated and trans fats intake, is one of the strongest factors contributing to the development of cardiovascular disease. With an historical approach, this paper aims to describe policies regarding trans fats in Argentina. Main global strategies which inspired local interventions are included: from North Karelia memorable project, through the Global Strategy on Diet, Physical Activity and Health to the Argentinian experience which made it possible to replace 70% of partially hydrogenated oil from the market.